Pennypacker Lab

My laboratory performs translational stroke research, our goal is to discover new therapeutic approaches for treatment. Our premier project, Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC), focuses on the identification of the molecular components in ischemic blood retrieved from human patients during stroke.

TH2 Immune Response‚Ä©

 

Ischemic distal and peripheral (proximal) arterial blood is collected from stroke patients during the mechanical thrombectomy procedure. Blood gases, electrolytes, protein and mRNA expression are analyzed from these blood samples. The employment of artificial intelligence has revealed, for the first time, the inflammatory response to the ischemic insult within the brains of patients during stroke (see TH2 immune response above).

Rat Model of Stroke

 

To develop therapeutics, we have created an experimental stroke model based on the thrombectomy procedure to test machine learning-derived targets using aged rats of both sexes. Shown here is the intra-arterial administration of dye demonstrating the penetrance of a drug administered in our rat model of stroke that mimics the thrombectomy procedure in human stroke patients. This study provides insight into therapeutic approaches aimed at inhibiting neurodegenerative effects of inflammation which are dependent on age and sex.

Keith Pennypacker, PhD

Professor

Departments of Neurology and Neuroscience

keith.pennypacker@uky.edu

Jacqueline Frank

Scientist I

j.frank@uky.edu

Sarah Messmer, MPH

Scientist I

sarah.goodwin2@uky.edu

For more information, contact the team behind the Center for Advanced Translational Stroke Science.

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